具有高弛豫率和光致发光特性的核/壳量子点用于多模态成像。
Core/shell quantum dots with high relaxivity and photoluminescence for multimodality imaging.
作者信息
Wang Shizhong, Jarrett Benjamin R, Kauzlarich Susan M, Louie Angelique Y
机构信息
Department of Chemistry, and Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
出版信息
J Am Chem Soc. 2007 Apr 4;129(13):3848-56. doi: 10.1021/ja065996d. Epub 2007 Mar 15.
Abstract
A series of core/shell CdSe/Zn1-xMnxS nanoparticles were synthesized for use in dual-mode optical and magnetic resonance (MR) imaging techniques. Mn2+ content was in the range of 0.6-6.2% and varies with the thickness of the shell or amount of Mn2+ introduced to the reaction. These materials showed high quantum yield (QY), reaching 60% in organic solvent. Water-soluble nanoparticles were obtained by capping the core/shell particles with amphiphilic polymer, and the QY values in water reached 21%. These materials also demonstrated high relaxivity with r1 values in the range of 11-18 mM-1 s-1 (at room temperature, 7 T). Both optical and MR imaging were performed on nanoparticles in aqueous solution and applied to cells in culture. The results showed that the QY and manganese concentration in the particles was sufficient to produce contrast for both modalities at relatively low concentrations of nanoparticles.
摘要
合成了一系列核/壳结构的CdSe/Zn1-xMnxS纳米粒子，用于双模式光学和磁共振（MR）成像技术。Mn2+含量在0.6 - 6.2%范围内，并随壳层厚度或引入反应中的Mn2+量而变化。这些材料显示出高量子产率（QY），在有机溶剂中达到60%。通过用两亲性聚合物包覆核/壳颗粒获得了水溶性纳米粒子，其在水中的QY值达到21%。这些材料还表现出高弛豫率，r1值在11 - 18 mM-1 s-1范围内（在室温下，7 T）。对水溶液中的纳米粒子进行了光学和MR成像，并应用于培养的细胞。结果表明，在相对低浓度的纳米粒子下，粒子中的QY和锰浓度足以产生两种模式的对比度。
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