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用于细胞成像的谷胱甘肽包覆的CdTe/CdSe近红外量子点的微波辅助合成

Microwave-Assisted Synthesis of Glutathione-Capped CdTe/CdSe Near-Infrared Quantum Dots for Cell Imaging.

作者信息

Chen Xiaogang, Li Liang, Lai Yongxian, Yan Jianna, Tang Yichen, Wang Xiuli

机构信息

Department of Dermatologic Surgery, Shanghai Skin Disease Hospital, Shanghai 200443, China.

出版信息

Int J Mol Sci. 2015 May 19;16(5):11500-8. doi: 10.3390/ijms160511500.

Abstract

These glutathione (GSH)-conjugated CdTe/CdSe core/shell quantum dot (QD) nanoparticles in aqueous solution were synthesized using a microwave-assisted approach. The prepared type II core/shell QD nanoparticles were characterized by UV-Vis absorption, photoluminescence (PL) spectroscopy, X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM). Results revealed that the QD nanoparticles exhibited good dispersity, a uniform size distribution and tunable fluorescence emission in the near-infrared (NIR) region. In addition, these nanoparticles exhibited good biocompatibility and photoluminescence in cell imaging. In particular, this type of core/shell NIR QDs may have potential applications in molecular imaging.

摘要

采用微波辅助法合成了水溶液中的这些谷胱甘肽(GSH)共轭的CdTe/CdSe核壳量子点(QD)纳米颗粒。通过紫外-可见吸收光谱、光致发光(PL)光谱、X射线粉末衍射(XRD)和高分辨率透射电子显微镜(HR-TEM)对制备的II型核壳量子点纳米颗粒进行了表征。结果表明,量子点纳米颗粒具有良好的分散性、均匀的尺寸分布以及在近红外(NIR)区域可调谐的荧光发射。此外,这些纳米颗粒在细胞成像中表现出良好的生物相容性和光致发光特性。特别是,这种类型的核壳近红外量子点在分子成像中可能具有潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba50/4463713/7d0772828d15/ijms-16-11500-g001.jpg

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