Goldman S L, Bosque E, McCann E, Lewis K
California Pacific Medical Center, San Francisco 94118.
J Pediatr. 1992 Feb;120(2 Pt 2):S25-8. doi: 10.1016/s0022-3476(05)81229-6.
During the double-blind, multicenter trials of the synthetic surfactant Exosurf Neonatal, we measured pulmonary mechanics at 28 days of age in 30 surfactant- or placebo-treated infants. In the 20 surfactant-treated and 10 air-treated infants studied, there were no differences in lung compliance or resistance at 28 days of age. These observations suggest that improvements in pulmonary function reported early in the neonatal course after the administration of exogenous surfactant are not detectable at 28 days of age.
在合成表面活性剂Exosurf Neonatal的双盲、多中心试验中，我们在30名接受表面活性剂或安慰剂治疗的婴儿28日龄时测量了肺力学指标。在研究的20名接受表面活性剂治疗的婴儿和10名接受空气治疗的婴儿中，28日龄时的肺顺应性或阻力没有差异。这些观察结果表明，在新生儿病程早期给予外源性表面活性剂后报告的肺功能改善在28日龄时无法检测到。
