Bose C, Corbet A, Bose G, Prats J G, Russell L, Edwards K
Department of Pediatrics, School of Medicine, University of North Carolina, Chapel Hill 27599.
J Pediatr. 1992 Feb;120(2 Pt 2):S13-7. doi: 10.1016/s0022-3476(05)81227-2.
During two randomized, controlled trials comparing single prophylactic doses of air placebo and a synthetic surfactant, Exosurf Neonatal, many routine laboratory measurements were made in small premature infants during the first week of life. Values for serum electrolytes, urea, creatinine, phospholipid, cholesterol, glucose, calcium, bilirubin, and liver enzymes, as well as for hemoglobin, leukocyte and platelet counts, and urinalysis, did not differ between the placebo- and surfactant-treated infants. There was no evidence that prophylactic administration of this synthetic surfactant causes alterations in standard laboratory tests in small premature infants.
在两项比较单次预防性剂量的空气安慰剂和一种合成表面活性剂（Exosurf Neonatal）的随机对照试验中，对出生后第一周的小早产儿进行了多项常规实验室检测。安慰剂组和表面活性剂治疗组婴儿的血清电解质、尿素、肌酐、磷脂、胆固醇、葡萄糖、钙、胆红素和肝酶值，以及血红蛋白、白细胞和血小板计数及尿液分析结果并无差异。没有证据表明这种合成表面活性剂的预防性给药会导致小早产儿的标准实验室检测结果出现改变。
