Liu Ying, Kathan Kendra, Saad Walid, Prud'homme Robert K
Department of Chemical Engineering, Princeton University, Princeton, New Jersey 08544, USA.
Phys Rev Lett. 2007 Jan 19;98(3):036102. doi: 10.1103/PhysRevLett.98.036102. Epub 2007 Jan 17.
Ostwald ripening, the interfacial-energy-driven dissolution and reprecipitation of solutes, becomes an increasingly significant problem for nanoparticle formulations. We present the first quantitative study of Ostwald ripening for nanoparticle dispersions. The Lifshitz-Slyozov-Wagner (LSW) theory of particle growth driven by diffusion is applied to study beta-carotene nanoparticles with sizes of O(100 nm) formed by our block-copolymer protected Flash Nanoprecipitation process. A numerical implementation of the LSW theory that accounts for the original particle size distribution is presented. The predicted particle sizes from the numerical simulation are compared with the experimental results measured by dynamical light scattering. The results show quantitative agreement with no adjustable parameters. The addition of antisolvent results in the reduction of the ripening rate by dramatically decreasing bulk solubility.
奥斯特瓦尔德熟化，即界面能驱动的溶质溶解和再沉淀，对于纳米颗粒制剂而言已成为一个日益严重的问题。我们首次对纳米颗粒分散体的奥斯特瓦尔德熟化作了定量研究。运用由扩散驱动的颗粒生长的 Lifshitz-Slyozov-Wagner（LSW）理论来研究通过我们的嵌段共聚物保护的快速纳米沉淀法形成的尺寸为 O(100 nm) 的β-胡萝卜素纳米颗粒。给出了考虑原始粒径分布的 LSW 理论的数值实现。将数值模拟预测的粒径与通过动态光散射测量的实验结果进行比较。结果显示在没有可调参数的情况下达成了定量一致。添加反溶剂通过大幅降低本体溶解度导致熟化速率降低。
