Jo Eun-Kyeong, Yang Chul-Su, Choi Chul Hee, Harding Clifford V
Department of Microbiology, and Medical Research Insttitutes, College of Medicine, Chungam National University, Daejeon 301-747, South Korea.
Cell Microbiol. 2007 May;9(5):1087-98. doi: 10.1111/j.1462-5822.2007.00914.x. Epub 2007 Mar 13.
Toll-like receptors (TLRs) recognize Mycobacterium tuberculosis (Mtb) or Mtb components and initiate mononuclear phagocyte responses that influence both innate and adaptive immunity. Recent studies have revealed the intracellular signalling cascades involved in the TLR-initiated immune response to mycobacterial infection. Although both TLR2 and TLR4 have been implicated in host interactions with Mtb, the relationship between specific mycobacterial molecules and various signal transduction pathways is not well understood. This review will discuss recent studies indicating critical roles for mycobacteria and mycobacterial components in regulation of mitogen-activated protein kinases and related signal transduction pathways that govern the outcome of infection and antibacterial defence. To better understand the roles of infection-induced signalling cascades in molecular pathogenesis, future studies are needed to clarify mechanisms that integrate the multiple signalling pathways that are activated by engagement of TLRs by both individual mycobacterial molecules and whole mycobacteria. These efforts will allow for the development of novel diagnostic and therapeutic modalities for tuberculosis that targets the intracellular signalling pathways permitting the replication of this nefarious pathogen.
Toll样受体（TLRs）识别结核分枝杆菌（Mtb）或Mtb成分，并启动单核吞噬细胞反应，影响固有免疫和适应性免疫。最近的研究揭示了TLR启动的针对分枝杆菌感染的免疫反应中涉及的细胞内信号级联反应。虽然TLR2和TLR4都与宿主与Mtb的相互作用有关，但特定分枝杆菌分子与各种信号转导途径之间的关系尚未完全了解。本综述将讨论最近的研究，这些研究表明分枝杆菌和分枝杆菌成分在调节丝裂原活化蛋白激酶和相关信号转导途径中起关键作用，这些途径决定感染结果和抗菌防御。为了更好地理解感染诱导的信号级联反应在分子发病机制中的作用，未来需要开展研究以阐明整合多种信号途径的机制，这些信号途径是由单个分枝杆菌分子和完整分枝杆菌与TLR结合而激活的。这些努力将有助于开发针对结核病的新型诊断和治疗方法，其靶向允许这种有害病原体复制的细胞内信号途径。
