用罗米定预处理的幼鸵鸟肌肉注射氯胺酮的药代动力学。

Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine.

作者信息

De Lucas J J, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés M I

机构信息

Cátedra de Farmacología, Farmacia y Terapéutica, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/Puerta de Hierro s.n., 28040 Madrid, Spain.

出版信息

J Vet Med A Physiol Pathol Clin Med. 2007 Feb;54(1):48-50. doi: 10.1111/j.1439-0442.2007.00910.x.

DOI:10.1111/j.1439-0442.2007.00910.x

PMID:17359455

Abstract

Ketamine is a short-acting dissociative anaesthetic for chemical restraint and surgical anaesthesia in domestic and non-domestic animals. The present study was designed to determine the pharmacokinetics of a single dose of ketamine (10 mg/kg) after intramuscular (i.m.) administration to young ostriches premedicated with romifidine. Ketamine was rapidly absorbed after i.m. administration. Maximal ketamine concentration (C(max)) of 2.93 +/- 0.61 microg/ml was reached at 12.5 +/- 2.50 min and thereafter ketamine concentrations decreased rapidly. The elimination half-life (t(1/2 z)) obtained was 62.37 +/- 17.37 min and mean residence time (MRT) was 77.33 +/- 19.12 min. The area under the curve (AUC) was 114.19 +/- 15.76 microg x min/ml.

摘要

氯胺酮是一种短效解离麻醉剂，用于家畜和非家畜的化学保定及外科麻醉。本研究旨在确定对预先使用罗米芬定进行预处理的幼鸵鸟肌肉注射单剂量氯胺酮（10毫克/千克）后的药代动力学。肌肉注射后，氯胺酮迅速吸收。在12.5±2.50分钟时达到最大氯胺酮浓度（C(max)），为2.93±0.61微克/毫升，此后氯胺酮浓度迅速下降。测得的消除半衰期（t(1/2 z)）为62.37±17.37分钟，平均驻留时间（MRT）为77.33±19.12分钟。曲线下面积（AUC）为114.19±15.76微克·分钟/毫升。