Manefield Mike, Whiteley Andrew S
Centre for Marine Biofouling and BioInnovation, University of New South Wasles, Sydney, Australia.
Philos Trans R Soc Lond B Biol Sci. 2007 Jul 29;362(1483):1235-40. doi: 10.1098/rstb.2007.2048.
Over the last 15 years, it has become increasingly apparent that a single class of compounds, the acylated homoserine lactones (AHLs), elicit effects on many levels of biological and ecological organization. Despite the fact that the distribution of AHL production in the prokaryotic phylogenetic tree is restricted to a small set of genera, representatives of these genera are abundant in the environment and are responsible for processes of much interest to humans. As well as driving interactions between clones, AHLs have been shown to mediate interactions between different species of bacteria and between bacteria and higher organisms, either through the phenotypes they regulate or directly through their own chemical behaviour. Understanding the biological activity of AHLs and the ecological consequences of these activities may provide us with an opportunity to manipulate the composition and function of complex biological assemblages. Ultimately, this broadens the biotechnological focus of AHL-based research beyond the attenuation of virulence in humans and plant pathogens.
在过去的15年里，越来越明显的是，一类单一的化合物，即酰化高丝氨酸内酯（AHLs），在生物和生态组织的多个层面上发挥作用。尽管AHLs在原核生物系统发育树中的产生分布仅限于一小部分属，但这些属的代表在环境中数量众多，并参与了许多人类感兴趣的过程。除了推动克隆之间的相互作用外，AHLs还被证明可以介导不同细菌物种之间以及细菌与高等生物之间的相互作用，无论是通过它们调节的表型还是直接通过它们自身的化学行为。了解AHLs的生物活性以及这些活性的生态后果，可能为我们提供一个机会来操纵复杂生物群落的组成和功能。最终，这拓宽了基于AHLs研究的生物技术重点，使其超越了人类和植物病原体中毒力的减弱。
