真核生物对高丝氨酸内酯介导的原核生物信号传导的干扰。
Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling.
作者信息
Givskov M, de Nys R, Manefield M, Gram L, Maximilien R, Eberl L, Molin S, Steinberg P D, Kjelleberg S
机构信息
Department of Microbiology, The Technical University of Denmark, Lyngby.
出版信息
J Bacteriol. 1996 Nov;178(22):6618-22. doi: 10.1128/jb.178.22.6618-6622.1996.
Abstract
Acylated homoserine lactones (AHLs) play a widespread role in intercellular communication among bacteria. The Australian macroalga Delisea pulchra produces secondary metabolites which have structural similarities to AHL molecules. We report here that these metabolites inhibited AHL-controlled processes in prokaryotes. Our results suggest that the interaction between higher organisms and their surface-associated bacteria may be mediated by interference with bacterial regulatory systems.
摘要
酰化高丝氨酸内酯（AHLs）在细菌间的细胞间通讯中发挥着广泛作用。澳大利亚大型海藻美丽德尔藻产生的次生代谢产物与AHL分子在结构上有相似之处。我们在此报告，这些代谢产物抑制了原核生物中AHL控制的过程。我们的结果表明，高等生物与其表面相关细菌之间的相互作用可能是通过干扰细菌调节系统来介导的。
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