神经元的集体生长与轴突的自我组织
Collective neuronal growth and self organization of axons.
作者信息
de Gennes P-G
机构信息
Centre de Recherche, Institut Curie, 26 Rue d'Ulm, 75231 Paris Cedex 05, France.
出版信息
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4904-6. doi: 10.1073/pnas.0609871104. Epub 2007 Mar 12.
Abstract
I describe an assembly of neurons that synthesizes a chemorepellant molecule and transfers this molecule to the growth cones by axonal transport. From the growth cone, the repellant diffuses in nearby regions, achieving a certain concentration profile, delta, with a gradient. The growth cone migrates preferentially toward the regions of low delta. I show that this process self-consistently generates a profile of finite width, with a relatively sharp front of neuronal growth.
摘要
我描述了一组神经元，它们合成一种化学排斥分子，并通过轴突运输将该分子传递到生长锥。排斥分子从生长锥扩散到附近区域，形成具有一定浓度分布δ且带有梯度的区域。生长锥优先向低δ区域迁移。我证明了这个过程能自洽地产生一个有限宽度的分布，形成一个相对尖锐的神经元生长前沿。
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