Kovács Krisztián A, Steullet Pascal, Steinmann Myriam, Do Kim Q, Magistretti Pierre J, Halfon Olivier, Cardinaux Jean-René
Center for Psychiatric Neuroscience and Service of Child and Adolescent Psychiatry, Department of Psychiatry, University Medical Center, University of Lausanne, CH-1008 Prilly-Lausanne, Switzerland.
Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4700-5. doi: 10.1073/pnas.0607524104. Epub 2007 Mar 6.
A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.
记忆过程的一个关键特征是通过关联将不同的输入信号联系起来，并在突触连接水平上保持这种耦合。晚期长时程增强（L-LTP）是一种被认为编码长期记忆的突触可塑性形式，它需要基因转录和蛋白质合成。在本研究中，我们报告了一种最近克隆的环磷酸腺苷反应元件结合蛋白（CREB）的共激活因子，称为CREB活性调节转导子1（TORC1），它通过感知神经元中钙信号和环磷酸腺苷信号的同时出现，并将其转化为转录反应，从而导致增强突触传递所需因子的合成，进而促进这一过程。我们提供的证据表明，TORC1参与海马体中谢弗侧支- CA1突触的L-LTP维持。
