Kloppenburg Margreet, Stamm Tanja, Watt Iain, Kainberger Franz, Cawston Tim E, Birrell Fraser N, Petersson Ingemar F, Saxne Tore, Kvien Tore K, Slatkowsky-Christensen Barbara, Dougados Maxime, Gossec Laure, Breedveld Ferdinand C, Smolen Josef S
Department of Rheumatology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.
Ann Rheum Dis. 2007 Sep;66(9):1157-61. doi: 10.1136/ard.2007.070813. Epub 2007 Mar 14.
Osteoarthritis of the hands is a prevalent musculoskeletal disease with a considerable effect on patients' lives, but knowledge and research results in the field of hand osteoarthritis are limited. Therefore, the Disease Characteristics in Hand OA (DICHOA) initiative was founded in early 2005 with the aim of addressing key issues and facilitating research into hand osteoarthritis.
To review and discuss current knowledge on hand osteoarthritis with regard to aetiopathogenesis, diagnostic criteria, biomarkers and clinical outcome measures.
Recommendations were made based on a literature review.
Outcomes of hand osteoarthritis should be explored, including patient perspective on the separate components of disease activity, damage and functioning. All imaging techniques should be cross-validated for hand osteoarthritis with clinical status, including disease activity, function and performance, biomarkers and long-term outcome. New imaging modalities are available and need scoring systems and validation. The role of biomarkers in hand osteoarthritis has to be defined.
Future research in hand osteoarthritis is warranted.
手部骨关节炎是一种常见的肌肉骨骼疾病，对患者生活有相当大的影响，但手部骨关节炎领域的知识和研究成果有限。因此，手部骨关节炎疾病特征（DICHOA）倡议于2005年初成立，旨在解决关键问题并促进手部骨关节炎的研究。
回顾和讨论关于手部骨关节炎的病因发病机制、诊断标准、生物标志物和临床结局指标的现有知识。
基于文献综述提出建议。
应探索手部骨关节炎的结局，包括患者对疾病活动、损伤和功能的各个组成部分的看法。所有成像技术都应与手部骨关节炎的临床状况进行交叉验证，包括疾病活动、功能和表现、生物标志物和长期结局。新的成像模式已经出现，需要评分系统和验证。必须明确生物标志物在手部骨关节炎中的作用。
手部骨关节炎的未来研究是必要的。
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