血管内皮生长因子与广州管圆线虫感染所致嗜酸性粒细胞性脑膜炎的血脑屏障功能障碍有关。
Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection.
作者信息
Tsai Hung-Chin, Liu Yung-Ching, Lee Susan Shin-Jung, Chen Eng-Rin, Yen Chuan-Min
机构信息
Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, and National Yang-Ming University, Taipei, Taiwan, Republic of China.
出版信息
Am J Trop Med Hyg. 2007 Mar;76(3):592-5.
Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGFCSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45-2190 pg/mL) at presentation. The mean VEGFCSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGFCSF, CSF protein, white cell count, and eosinophil counts. The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis.
血管内皮生长因子（VEGF）是一种强效的血管通透性因子，也是脑水肿的介质。为评估血管内皮生长因子在嗜酸性粒细胞性脑膜炎中的作用，在一项队列研究中对9例嗜酸性粒细胞性脑膜炎患者的脑脊液（CSF）和血液中的血管内皮生长因子进行了检测。9例嗜酸性粒细胞性脑膜炎患者中有8例（90%）在就诊时检测到脑脊液血管内皮生长因子（VEGFCSF）（范围为45 - 2190 pg/mL）。入院时、入院1周和2周时脑脊液血管内皮生长因子的平均值分别为568 pg/mL、751 pg/mL和1031 pg/mL。脑脊液血管内皮生长因子、脑脊液蛋白、白细胞计数和嗜酸性粒细胞计数之间存在关联。血清血管内皮生长因子（VEGFSERUM）在6个月的随访期内有所波动。这些结果表明，血管内皮生长因子可能与嗜酸性粒细胞性脑膜炎患者的血脑屏障破坏有关。
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