Francis A Heather, Martin Linda G, Haldorson Gary J, Lahmers Kevin K, Luther Teresa Y, Alperin Debra C, Hines Stephen A
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA.
J Am Vet Med Assoc. 2007 Mar 15;230(6):873-9. doi: 10.2460/javma.230.6.873.
6 healthy dogs given human albumin solution as part of a study were examined following development of an immediate hypersensitivity reaction (1 dog) and signs suggestive of a type III hypersensitivity reaction (all 6 dogs).
All 6 dogs were healthy prior to administration of human albumin solution. One dog developed signs of an immediate hypersensitivity reaction, characterized by vomiting and facial edema, during administration of human albumin solution. All 6 dogs developed signs of a delayed adverse reaction 5 to 13 days after administration of human albumin solution. Initial clinical signs included lethargy, lameness, edema, cutaneous lesions indicative of vasculitis, vomiting, and inappetance.
In the dog with signs of immediate hypersensitivity, signs resolved after administration of human albumin solution was discontinued and diphenhydramine was administered. Supportive treatment was provided after dogs developed signs of a delayed adverse reaction. Four dogs recovered, but 2 dogs died despite treatment. All 6 dogs were found to have antihuman albumin antibodies. There was no evidence of contamination of the human albumin solution.
Findings suggest that administration of human albumin solution in healthy dogs with normal serum albumin concentrations may result in signs of a type III hypersensitivity reaction.
作为一项研究的一部分，给6只健康犬输注人白蛋白溶液后，对出现速发型超敏反应的1只犬以及出现疑似Ⅲ型超敏反应体征的所有6只犬进行了检查。
在输注人白蛋白溶液之前，所有6只犬均健康。1只犬在输注人白蛋白溶液期间出现速发型超敏反应体征，表现为呕吐和面部水肿。所有6只犬在输注人白蛋白溶液后5至13天出现迟发性不良反应体征。最初的临床体征包括嗜睡、跛行、水肿、提示血管炎的皮肤病变、呕吐和食欲不振。
出现速发型超敏反应体征的犬在停止输注人白蛋白溶液并给予苯海拉明后，体征消退。犬出现迟发性不良反应体征后给予支持性治疗。4只犬康复，但2只犬尽管接受了治疗仍死亡。所有6只犬均检测到抗人白蛋白抗体。没有证据表明人白蛋白溶液受到污染。
研究结果表明，在血清白蛋白浓度正常的健康犬中输注人白蛋白溶液可能会导致Ⅲ型超敏反应体征。
