Westermann Stefan, Drubin David G, Barnes Georjana
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Annu Rev Biochem. 2007;76:563-91. doi: 10.1146/annurev.biochem.76.052705.160607.
The kinetochore is a key cell division organelle that enables high-fidelity transmission of genetic information by coupling chromosomes to spindle microtubules during mitosis and meiosis. Despite its cytological description more than a century ago, remarkably little information is available on kinetochore function at a molecular level. Recently, important advances elucidating the overall organization of kinetochores, as well as information about the structures and molecular mechanisms of kinetochore function, have been achieved through a detailed analysis of the kinetochores of the budding yeast Saccharomyces cerevisiae. Here we review the current understanding of kinetochore function in budding yeast and draw comparisons to recent findings in other organisms.
动粒是一种关键的细胞分裂细胞器，它通过在有丝分裂和减数分裂期间将染色体与纺锤体微管相连，实现遗传信息的高保真传递。尽管一个多世纪前就有了关于它的细胞学描述，但在分子水平上关于动粒功能的信息却非常少。最近，通过对芽殖酵母酿酒酵母动粒的详细分析，在阐明动粒的整体组织以及动粒功能的结构和分子机制方面取得了重要进展。在这里，我们综述了目前对芽殖酵母动粒功能的理解，并与其他生物体中的最新发现进行比较。
