他莫昔芬可预防玉米赤霉醇（一种具有雌激素活性的食品污染物）诱导的肝脏肿瘤形成。
Tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant.
作者信息
Coe J E, Ishak K G, Ward J M, Ross M J
机构信息
National Institutes of Health, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840.
出版信息
Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1085-9. doi: 10.1073/pnas.89.3.1085.
Abstract
Zeranol (alpha-zearalanol) is a beta-resorcylic acid lactone (RAL) that has estrogen activity. It is synthesized by molds and is difficult to avoid in human food products. We tested the ability of this mycoestrogen to damage the liver of the Armenian hamster, a rodent that is especially sensitive to hepatotoxic effects of exogenous estrogens. Zeranol induced acute hepatotoxicity and, subsequently, hepatic carcinogenesis; both effects were blocked by tamoxifen, suggesting estrogen receptor mediation. Because zeranol is acting alone as a primary initiator of hepatic neoplasms, this model provides an unusual opportunity to study the pathogenesis of estrogen-initiated tumorigenesis.
摘要
玉米赤霉醇（α-玉米赤霉醇）是一种具有雌激素活性的β-间苯二酚内酯（RAL）。它由霉菌合成，在人类食品中难以避免。我们测试了这种霉菌雌激素对亚美尼亚仓鼠肝脏的损害能力，亚美尼亚仓鼠是一种对外源性雌激素的肝毒性作用特别敏感的啮齿动物。玉米赤霉醇诱发了急性肝毒性，随后引发了肝癌；这两种效应均被他莫昔芬阻断，提示由雌激素受体介导。由于玉米赤霉醇单独作为肝脏肿瘤的主要引发剂起作用，该模型为研究雌激素引发的肿瘤发生机制提供了一个独特的机会。
相似文献
1
Tamoxifen prevents induction of hepatic neoplasia by zeranol, an estrogenic food contaminant.他莫昔芬可预防玉米赤霉醇（一种具有雌激素活性的食品污染物）诱导的肝脏肿瘤形成。
Proc Natl Acad Sci U S A. 1992 Feb 1;89(3):1085-9. doi: 10.1073/pnas.89.3.1085.
2
Estrogen-induced hepatic toxicity and hepatic cancer: differences between two closely related hamster species.
Liver. 1998 Oct;18(5):343-51. doi: 10.1111/j.1600-0676.1998.tb00816.x.
3
Tamoxifen inhibits estrogen-induced hepatic injury in hamsters.
Endocrinology. 1988 Jan;122(1):137-44. doi: 10.1210/endo-122-1-137.
4
Zeranol--a 'nature-identical' oestrogen?
Food Chem Toxicol. 1985 Aug;23(8):767-74. doi: 10.1016/0278-6915(85)90273-x.
5
6
Oral zeranol shortens the prolonged bleeding time of uremic rats.
Kidney Int. 1990 Jul;38(1):96-100. doi: 10.1038/ki.1990.172.
7
Biphasic effects of zeranol on the growth of estrogen receptor-positive human breast carcinoma cells.玉米赤霉醇对雌激素受体阳性人乳腺癌细胞生长的双相作用。
Oncol Rep. 2006 Dec;16(6):1307-12.
8
The mycoestrogen zeranol at high dosage antagonizes transient receptor potential channel activities in 3T3 L1 cells.高剂量的真菌雌激素玉米赤霉醇会拮抗 3T3 L1 细胞中的瞬时受体电位通道活性。
Toxicol Lett. 2021 Jun 15;344:18-25. doi: 10.1016/j.toxlet.2021.03.003. Epub 2021 Mar 6.
9
Catechol metabolites of zeranol and 17β-estradiol: a comparative in vitro study on the induction of oxidative DNA damage and methylation by catechol-O-methyltransferase.玉米赤霉醇和 17β-雌二醇的儿茶酚代谢物：儿茶酚-O-甲基转移酶对氧化 DNA 损伤和甲基化诱导的体外比较研究。
Toxicol Lett. 2012 Apr 5;210(1):9-14. doi: 10.1016/j.toxlet.2012.01.010. Epub 2012 Jan 20.
10
Estrogenic potencies of resorcylic acid lactones and 17 beta-estradiol in female rats.
J Toxicol Environ Health. 1987;20(4):435-43. doi: 10.1080/15287398709530995.
引用本文的文献
1
Synergistic estrogenic effects of Fusarium and Alternaria mycotoxins in vitro.镰刀菌和链格孢霉菌毒素在体外的协同雌激素效应。
Arch Toxicol. 2017 Mar;91(3):1447-1460. doi: 10.1007/s00204-016-1795-7. Epub 2016 Jul 11.
2
Hormone Use in Food Animal Production: Assessing Potential Dietary Exposures and Breast Cancer Risk.动物生产中激素的使用：评估潜在的饮食暴露和乳腺癌风险。
Curr Environ Health Rep. 2015 Mar;2(1):1-14. doi: 10.1007/s40572-014-0042-8.
3
Zeranol may increase the risk of leptin-induced neoplasia in human breast.玉米赤霉醇可能会增加人体乳腺中瘦素诱导的肿瘤形成风险。
Oncol Lett. 2011 Jan;2(1):101-108. doi: 10.3892/ol.2010.214. Epub 2010 Nov 23.
4
Zeranol down-regulates p53 expression in primary cultured human breast cancer epithelial cells through epigenetic modification.玉米赤霉醇通过表观遗传修饰下调原代培养的人乳腺癌上皮细胞中p53的表达。
Int J Mol Sci. 2011;12(3):1519-32. doi: 10.3390/ijms12031519. Epub 2011 Feb 25.
5
Role of zearalenone lactonase in protection of Gliocladium roseum from fungitoxic effects of the mycotoxin zearalenone.玉米赤霉烯酮内酯酶在保护粉红粘帚霉免受霉菌毒素玉米赤霉烯酮的真菌毒性影响中的作用。
Appl Environ Microbiol. 2007 Jan;73(2):637-42. doi: 10.1128/AEM.01440-06. Epub 2006 Nov 17.
6
A sensitive zonagenetic assay for rapid in vitro assessment of estrogenic potency of xenobiotics and mycotoxins.一种用于快速体外评估外源性化学物质和霉菌毒素雌激素活性的灵敏区域发生分析方法。
Environ Health Perspect. 1999 Jan;107(1):63-8. doi: 10.1289/ehp.9910763.
本文引用的文献
1
Hormones, medications, and cancer.
Cancer. 1983 Jun 15;51(12 Suppl):2426-9. doi: 10.1002/1097-0142(19830615)51:12+<2426::aid-cncr2820511307>3.0.co;2-c.
2
Diethylstilbestrol-induced jaundice in the Chinese and Armenian hamster.
Hepatology. 1983 Jul-Aug;3(4):489-96. doi: 10.1002/hep.1840030404.
3
Binding properties of zearalenone mycotoxins to hepatic estrogen receptors.
Mol Pharmacol. 1981 Jul;20(1):35-42.
4
The pharmacology and clinical uses of tamoxifen.他莫昔芬的药理学及临床应用。
Pharmacol Ther. 1984;25(2):127-205. doi: 10.1016/0163-7258(84)90043-3.
5
Tamoxifen is a calmodulin antagonist in the activation of cAMP phosphodiesterase.他莫昔芬在激活环磷酸腺苷磷酸二酯酶过程中是一种钙调蛋白拮抗剂。
Biochem Biophys Res Commun. 1984 Jan 13;118(1):27-32. doi: 10.1016/0006-291x(84)91062-3.
6
Hepatocellular carcinoma and oral contraceptives.肝细胞癌与口服避孕药
Br J Cancer. 1983 Sep;48(3):437-40. doi: 10.1038/bjc.1983.210.
7
Experimental production of Mallory bodies in mice by diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
Gastroenterology. 1982 Jul;83(1 Pt 1):109-13.
8
The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen.神经癌基因：一个与erb-B相关的基因，编码一种分子量为185,000的肿瘤抗原。
Nature. 1984;312(5994):513-6. doi: 10.1038/312513a0.
9
Hepatic tumors induced by sex steroids.性类固醇诱导的肝肿瘤。
Semin Liver Dis. 1984 May;4(2):147-57. doi: 10.1055/s-2008-1040654.
10
Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women.阴道腺癌。年轻女性母亲接受己烯雌酚治疗与肿瘤出现的关联。
N Engl J Med. 1971 Apr 22;284(15):878-81. doi: 10.1056/NEJM197104222841604.
Zotero 插件