Wang Yu, Xu Kedi, Lin Lin, Pan Yuanjiang, Zheng Xiaoxiang
Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.
Phytochemistry. 2007 May;68(9):1300-6. doi: 10.1016/j.phytochem.2007.01.009. Epub 2007 Mar 23.
Five geranyl dihydrochalcones, 1-(2,4-dihydroxyphenyl)-3-{4-hydroxy-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo[b,d]pyran-5-yl}-1-propanone (2), 1-(2,4-dihydroxyphenyl)-3-[3,4-dihydro-3,8-dihydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (4), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(3,4-epoxy-4-methyl-1-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (5), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-hydroxy-4-methyl-2-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (8), and 2-[6-hydroxy-3,7-dimethylocta-2(E),7-dienyl]-2',3,4,4'-tetrahydroxydihydrochalcone (9), along with four known geranyl flavonoids (1, 3, 6, 7), were isolated from the leaves of Artocarpus altilis. Their structures were established by spectroscopic means and by comparison with the literature values. Compounds 2, 4, and 9 exhibited moderate cytotoxicity against SPC-A-1, SW-480, and SMMC-7721 human cancer cells.
从面包树的叶子中分离出了五种香叶基二氢查耳酮，即1-(2,4-二羟基苯基)-3-{4-羟基-6,6,9-三甲基-6a,7,8,10a-四氢-6H-二苯并[b,d]吡喃-5-基}-1-丙酮(2)、1-(2,4-二羟基苯基)-3-[3,4-二氢-3,8-二羟基-2-甲基-2-(4-甲基-3-戊烯基)-2H-1-苯并吡喃-5-基]-1-丙酮(4)、1-(2,4-二羟基苯基)-3-[8-羟基-2-甲基-2-(3,4-环氧-4-甲基-1-戊烯基)-2H-1-苯并吡喃-5-基]-1-丙酮(5)、1-(2,4-二羟基苯基)-3-[8-羟基-2-甲基-2-(4-羟基-4-甲基-2-戊烯基)-2H-1-苯并吡喃-5-基]-1-丙酮(8)和2-[6-羟基-3,7-二甲基辛-2(E),7-二烯基]-2',3,4,4'-四羟基二氢查耳酮(9)，以及四种已知的香叶基黄酮(1、3、6、7)。通过光谱手段并与文献值比较确定了它们的结构。化合物2、4和9对人肺癌细胞SPC-A-1、人结肠癌细胞SW-480和人肝癌细胞SMMC-7721表现出中等细胞毒性。
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