Mucci Armida, Galderisi Silvana, Kirkpatrick Brian, Bucci Paola, Volpe Umberto, Merlotti Eleonora, Centanaro Fausto, Catapano Francesco, Maj Mario
Department of Psychiatry, University of Naples SUN, Largo Madonna delle Grazie, 80138 Naples, Italy.
Schizophr Res. 2007 May;92(1-3):252-61. doi: 10.1016/j.schres.2007.01.026. Epub 2007 Mar 23.
It has been proposed that the presence of enduring, idiopathic negative symptoms define a group of patients with a disease (deficit schizophrenia, DS) that is separate from other forms of schizophrenia (nondeficit schizophrenia, NDS). Although several findings support this hypothesis, the possibility that DS represents the severe end of a single schizophrenia continuum cannot be excluded yet. We tested the hypothesis that DS and NDS differ relative to event-related potentials (ERPs). Amplitude, scalp topography and cortical sources of the ERP components were assessed in clinically stable DS and NDS outpatients and in matched healthy subjects (HCS). Twenty subjects per group were recruited. Among the subjects who completed the target detection task, there were no group difference in accuracy. For N1, only patients with DS, as compared with HCS, showed an amplitude reduction over the scalp central leads and a reduced current source density in cingulate and parahippocampal gyrus. For P3, only patients with NDS, as compared with HCS, showed a lateralized amplitude reduction over the left posterior regions and reduced current source density in left temporal and bilateral frontal, cingulate and parietal areas. The DS and NDS groups differed significantly from each other with regard to N1 amplitude and topography, as well as P3 amplitude and cortical sources. The N1 was affected in DS but not in NDS patients, whereas P3 was affected in NDS only. This double dissociation is consistent with the hypothesis that DS represents a separate disease entity within schizophrenia.
有人提出,持续性特发性阴性症状的存在定义了一组患有某种疾病(缺陷型精神分裂症,DS)的患者,该疾病与其他形式的精神分裂症(非缺陷型精神分裂症,NDS)不同。尽管有几项研究结果支持这一假设,但DS代表单一精神分裂症连续谱严重端的可能性尚未排除。我们检验了DS和NDS在事件相关电位(ERP)方面存在差异的假设。在临床症状稳定的DS和NDS门诊患者以及匹配的健康受试者(HCS)中评估了ERP成分的振幅、头皮地形图和皮质源。每组招募20名受试者。在完成目标检测任务的受试者中,各组在准确性方面没有差异。对于N1,与HCS相比,只有DS患者在头皮中央导联上显示振幅降低,扣带回和海马旁回的电流源密度降低。对于P3,与HCS相比,只有NDS患者在左后区域显示出侧向振幅降低,左颞叶以及双侧额叶、扣带回和顶叶区域的电流源密度降低。DS组和NDS组在N1振幅和地形图以及P3振幅和皮质源方面存在显著差异。N1在DS患者中受到影响,而在NDS患者中未受影响,而P3仅在NDS患者中受到影响。这种双重分离与DS代表精神分裂症中一个独立疾病实体的假设一致。