López-Díaz Álvaro, Lara Ignacio, Lahera Guillermo
Mental Health Clinical Management Unit Virgen Macarena University Hospital, Seville, Spain.
Department of Medicine and Medical Specialties University of Alcalá, IryCIS, CIBERSAM, Madrid, Spain.
Psychiatry Investig. 2018 Jan;15(1):94-98. doi: 10.4306/pi.2018.15.1.94. Epub 2018 Jan 16.
The primary and enduring presence of negative symptoms observed in a relatively homogeneous subgroup of patients with schizophrenia led to the concept of deficit syndrome (DS). Until date, it is considered that 20-25% of schizophrenia cohorts have DS. The aim of this meta-analysis was to determine the current prevalence of DS, including international and most recent studies. Thirteen observational studies met the inclusion criteria, comprising 2092 patients from eight countries. Pooled proportion of the DS subgroup was 32.64%, higher than previously reported. Based on our outcomes, up to one-third of patients with schizophrenia might have idiopathic and stable negative symptoms. This significant proportion of patients should be well represented in clinical trial's samples.
在精神分裂症患者相对同质的亚组中观察到的阴性症状的主要且持久存在导致了缺陷综合征（DS）的概念。迄今为止，人们认为20%-25%的精神分裂症患者群体患有DS。本荟萃分析的目的是确定DS的当前患病率，包括国际和最新研究。13项观察性研究符合纳入标准，包括来自8个国家的2092名患者。DS亚组的合并比例为32.64%，高于先前报道。根据我们的结果，高达三分之一的精神分裂症患者可能有特发性和稳定的阴性症状。这一相当比例的患者在临床试验样本中应有充分的代表性。
