半乳糖凝集素-1在成体神经干细胞中的表达与功能
Expression and function of galectin-1 in adult neural stem cells.
作者信息
Sakaguchi M, Imaizumi Y, Okano H
机构信息
Department of Physiology, Keio University School of Medicine, Shinanomachi, Tokyo, Japan.
出版信息
Cell Mol Life Sci. 2007 May;64(10):1254-8. doi: 10.1007/s00018-007-6476-5.
Abstract
Neural stem cells (NSCs) in the adult mammalian brain proliferate and continuously produce new neurons. To date, there has been little research into the functions of lectins in adult NSCs. Recently, we reported that a lectin, galectin-1, is expressed on adult NSCs and promotes their proliferation through its carbohydrate-binding ability. This evidence raises the possibility that glycans play roles in the proliferation of adult NSCs.
摘要
成年哺乳动物大脑中的神经干细胞（NSCs）会增殖并持续产生新的神经元。迄今为止，关于凝集素在成年神经干细胞中的功能研究甚少。最近，我们报道了一种凝集素——半乳糖凝集素-1，在成年神经干细胞上表达，并通过其碳水化合物结合能力促进神经干细胞的增殖。这一证据增加了聚糖在成年神经干细胞增殖中发挥作用的可能性。
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