Cobb G P, Moore A W, Rummel K T, Adair B M, McMurry S T, Hooper M J
The Institute of Environmental and Human Health and Department of Environmental Toxicology, Texas Tech University, Lubbock, Texas 79409, USA.
Arch Environ Contam Toxicol. 2007 Apr;52(3):441-9. doi: 10.1007/s00244-006-0006-6. Epub 2007 Mar 15.
Methylmercury cation (MeHg) and divalent mercury (Hg++) accumulation in liver, kidney, and brain were quantified in prairie voles (Microtus ochrogaster) at 0, 3, 6, and 12 weeks during chronic exposure to aqueous MeHg. Dose groups received deionized water or aqueous solutions containing 9, 103, or 920 ng MeHg/ml. Our study presents temporal patterns of Hg++ and MeHg concentrations in organ tissues and makes inter-tissue comparisons at each time point to illustrate the accumulation and distribution of Hg species during the study. MeHg was accumulated in tissues for 3 weeks and then concentrations plateaued. Mercury accumulated in brain, liver, and kidney to average concentrations of 510 ng/g, 180 ng/g, and 3400 ng/g, respectively. MeHg and Hg++ concentrations were roughly equivalent in liver, kidney, and urine. MeHg concentrations in brain tissue were 2 to 20 times the concentrations of Hg++. Regression analysis was also used to demonstrate the utility of urinalysis as an indicator of Hg++ and MeHg concentrations in organ tissue (p < 0.001).
在对草原田鼠（Microtus ochrogaster）进行慢性暴露于甲基汞水溶液的过程中，对其在0、3、6和12周时肝脏、肾脏和大脑中甲基汞阳离子（MeHg）和二价汞（Hg++）的积累情况进行了定量分析。剂量组分别接受去离子水或含有9、103或920 ng MeHg/ml的水溶液。我们的研究呈现了器官组织中Hg++和MeHg浓度的时间模式，并在每个时间点进行组织间比较，以说明研究期间汞物种的积累和分布情况。MeHg在组织中积累3周后浓度趋于平稳。汞在大脑、肝脏和肾脏中的平均积累浓度分别为510 ng/g、180 ng/g和3400 ng/g。肝脏、肾脏和尿液中的MeHg和Hg++浓度大致相当。脑组织中的MeHg浓度是Hg++浓度的2至20倍。还使用回归分析来证明尿液分析作为器官组织中Hg++和MeHg浓度指标的效用（p < 0.001）。
