Chmurzynska A, Szydlowski M, Stachowiak M, Stankiewicz M, Switonski M
Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University of Poznan, Poland.
Anim Biotechnol. 2007;18(1):37-44. doi: 10.1080/10495390600671560.
Associations between FABP3 (alternatively named H-FABP) gene polymorphisms and fatness traits were tested in two pig breeds (Polish Large White and Polish Landrace) and one synthetic line - 990. Three known single nucleotide polymorphisms, detected by HinfI, MspI and HaeIII restriction enzymes, were analyzed. Moreover, three new polymorphisms in the 5' regulatory region were identified: C(-221)T, C(-160)G and T(-158)G, but only the third one was widely distributed and correlated with backfat thickness in line 990. The obtained results suggest that the FABP3 gene is linked with an unknown gene directly affecting backfat thickness, but the analyzed polymorphisms do not influence fatness traits.
在两个猪品种（波兰大白猪和波兰长白猪）以及一个合成系990中，检测了脂肪酸结合蛋白3（又称心脏型脂肪酸结合蛋白，H-FABP）基因多态性与脂肪性状之间的关联。分析了通过HinfI、MspI和HaeIII限制性内切酶检测到的三种已知单核苷酸多态性。此外，在5'调控区鉴定出三个新的多态性：C(-221)T、C(-160)G和T(-158)G，但只有第三个多态性分布广泛，且与990系的背膘厚度相关。所得结果表明，FABP3基因与一个直接影响背膘厚度的未知基因连锁，但所分析的多态性不影响脂肪性状。
