Oosterlinck W, Verbeeck R, Cuvelier C, Vergauwe D
Department of Urology, State University of Ghent, Belgium.
Urol Res. 1992;20(1):19-21. doi: 10.1007/BF00294329.
Calcium chelating agents, such as ethylenediaminetetraacetate are toxic to urothelium. Their capacity to form complexes with calcium ions, which is the basis for their chemolytical effectiveness, also determines their toxicity. A decrease of chemolytical effectiveness by prior saturation of the chelator with Ca2+ or by lowering the pH to levels unfavourable for calcium binding significantly diminishes tissue injury. Exchange of Mg2+ ions does not, however, diminish tissue damage. The clinical use of calcium ligands is therefore unsafe.
