Verplaetse H, Verbeeck R M, Verbaeys A, Oosterlinck W
J Urol. 1986 Mar;135(3):608-11. doi: 10.1016/s0022-5347(17)45760-0.
The effect of the addition of a buffer to an ethylenediaminetetracetic acid (EDTA) litholytic solution on the solubility of calcium oxalate monohydrate and hydroxyapatite is investigated. The experiments show that the addition of triethanolamine as a buffer to EDTA solutions at pH 8 and 8.5 enhances the solubility of these salts, confirming theoretical predictions. The solubility of calcium oxalate monohydrate at 25C in solutions with varying ratios of buffer to EDTA concentrations and an osmolality of 0.9 was determined. The solutions resulting in the highest solubility were finally tested for their litholytic ability at 37C. At pH 8 solubilities of 22.5 g X l-1 for calcium oxalate monohydrate and 20.2 g X l-1 for hydroxyapatite were obtained. The corresponding solubilities at pH 8.5 were respectively 24.5 g X l-1 and 19.2 g X l-1.
研究了向乙二胺四乙酸（EDTA）溶石溶液中添加缓冲剂对一水合草酸钙和羟基磷灰石溶解度的影响。实验表明，在pH值为8和8.5的EDTA溶液中添加三乙醇胺作为缓冲剂可提高这些盐的溶解度，证实了理论预测。测定了25℃下，缓冲剂与EDTA浓度比例不同且重量克分子渗透压浓度为0.9的溶液中一水合草酸钙的溶解度。最终测试了溶解度最高的溶液在37℃时的溶石能力。在pH值为8时，一水合草酸钙的溶解度为22.5 g·L-1，羟基磷灰石的溶解度为20.2 g·L-1。在pH值为8.5时，相应的溶解度分别为24.5 g·L-1和19.2 g·L-1。
