Kuykendall J R, Jarvi E J, Finley B L, Paustenbach D J
ChemRisk, Boulder, Colorado 80301, USA.
Drug Chem Toxicol. 2007;30(1):1-16. doi: 10.1080/01480540601017603.
Exposure to aldehydes represents potential risks to human and animal health. Cyclic aldehydes such as benzaldehyde, 2-furaldehyde, and paraldehyde were found to induce formation of stable DNA-protein cross-links (DPXs) in cultured human lymphoma cells. A relationship between increased cytotoxicity and DPX formation was observed with each aldehyde. Paraldehyde is a sedative drug used predominately in treatment of ethanol withdrawal. Paraldehyde was the most potent cross-linking aldehyde studied, yet least cytotoxic. Although DPX formation by aliphatic aldehydes is well-known, this study confirms the potential for cyclic aldehydes to cause formation of DPXs in cultured cells at therapeutically relevant doses.
接触醛类对人类和动物健康构成潜在风险。已发现诸如苯甲醛、2-糠醛和三聚乙醛等环状醛类可在培养的人淋巴瘤细胞中诱导形成稳定的DNA-蛋白质交联（DPX）。观察到每种醛类的细胞毒性增加与DPX形成之间存在关联。三聚乙醛是一种主要用于治疗乙醇戒断的镇静药物。三聚乙醛是所研究的最有效的交联醛类，但细胞毒性最小。尽管脂肪族醛类形成DPX是众所周知的，但本研究证实了环状醛类在治疗相关剂量下在培养细胞中导致形成DPX的可能性。
