Zeller J A, Dayhoff R E, Eurenius K, Russell W, Ledley R S
Clin Lab Haematol. 1984;6(2):145-55. doi: 10.1111/j.1365-2257.1984.tb00537.x.
Formaldehyde, acetaldehyde, malondialdehyde, glutaraldehyde and paraldehyde, when added in vitro to platelet-rich plasma, generate a similar distinct platelet aggregation response which is dose dependent when measured with a manual visual microscopic technique and by computerized image analysis, 'computerized platelet aggregation analysis'. Light transmission aggregometry did not measure this aggregation in a reliable manner. The aggregating reaction was specific to the aldehyde group and was not seen when the aldehyde was replaced by an alcohol, ketone, or acetate group in the case of acetaldehyde. The maximal aggregating effect of these aldehydes was directly proportional to the number of aldehyde groups per molecule. Aggregation was found to require the presence of plasma, but not von Willebrand's factor.
甲醛、乙醛、丙二醛、戊二醛和仲甲醛在体外添加到富含血小板的血浆中时，会产生类似的明显血小板聚集反应。当使用手动视觉显微镜技术和计算机图像分析（计算机化血小板聚集分析）进行测量时，这种反应呈剂量依赖性。光透射比浊法无法可靠地测量这种聚集。聚集反应对醛基具有特异性，在乙醛的情况下，当醛基被醇、酮或乙酸基团取代时，未观察到聚集。这些醛的最大聚集效应与每个分子中的醛基数直接成正比。发现聚集需要血浆的存在，但不需要血管性血友病因子。
