Kelleher J P, Shah V, Godley M L, Wakefield A J, Gordon I, Ransley P G, Snell M E, Risdon R A
Department of Urology, Institute of Child Health, London, UK.
Urol Res. 1992;20(1):63-5. doi: 10.1007/BF00294338.
Segmental renal scarring occurs in experimental obstructive uropathy in the multipapillary porcine kidney, and segmental abnormalities in renal perfusion are likely to be responsible. This preliminary study examines the urinary excretion of the potent locally active vasoconstrictor endothelin 1 (ET 1) in a pig model of renal obstruction and subsequent relief. Significant urinary excretion of ET 1 from the postobstructive kidney was found to occur after longstanding obstruction. Preglomerular arteriolar stenosis may be the cause of the renal ischaemia in obstruction that is at first reversible but later becomes irreversible if the stimulus persists. ET 1 may be implicated in the pathogenesis of this injury.
节段性肾瘢痕形成见于多乳头猪肾的实验性梗阻性尿路病中，肾灌注的节段性异常可能是其原因。这项初步研究检测了肾梗阻及随后梗阻解除的猪模型中强效局部活性血管收缩剂内皮素1（ET-1）的尿排泄情况。发现长期梗阻后，梗阻侧肾脏有大量ET-1经尿液排出。肾缺血可能是由肾小体前小动脉狭窄引起的，起初这种缺血是可逆的，但如果刺激持续存在，随后会变成不可逆的。ET-1可能参与了这种损伤的发病机制。
