Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T
Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
Nature. 1988 Mar 31;332(6163):411-5. doi: 10.1038/332411a0.
An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelin is an endogenous modulator of voltage-dependent ion channels. Expression of the endothelin gene is regulated by several vasoactive agents, indicating the existence of a novel cardiovascular control system.
一种内皮衍生的由21个氨基酸组成的血管收缩肽——内皮素已被分离出来，并被证明是已知的最有效的血管收缩剂之一。前内皮素互补DNA的克隆和测序表明，成熟的内皮素是通过一种不寻常的蛋白水解过程产生的，并且与一组神经毒素的区域同源性表明内皮素是电压依赖性离子通道的内源性调节剂。内皮素基因的表达受几种血管活性物质的调节，这表明存在一种新的心血管控制系统。
