Vibo Riina, Kõrv Janika, Roose Mai, Kampus Priit, Muda Piibe, Zilmer Kersti, Zilmer Mihkel
Department of Neurology and Neurosurgery, University of Tartu, Estonia.
Free Radic Res. 2007 Mar;41(3):282-7. doi: 10.1080/10715760601083235.
The goal of our study was to investigate the associations of oxidized LDL (apoB100 aldehyde-modified form) and acute phase proteins (fibrinogen, CRP) with acute ischemic stroke severity and outcome.
The study included 61 ischemic stroke patients and 64 controls. Strokes were subtyped according to TOAST criteria, the severity and outcome of stroke (at 1 year) were measured.
The mean triglyceride, fibrinogen, CRP and glucose values were significantly higher among cases. The median oxLDL value for patients with large artery atherosclerosis (LAA) type of stroke was significantly higher than for other subtypes. The oxLDL values did not correlate with age, stroke severity and outcome.
Inflammatory markers (fibrinogen and CRP) predicted the stroke severity and outcome whereas elevation of oxLDL levels did not. Our data refer to possibility that there may exist some links between the LAA subtype of stroke and elevated oxLDL (apoB100 aldehyde-modified form).
我们研究的目的是调查氧化型低密度脂蛋白（载脂蛋白B100醛修饰形式）和急性期蛋白（纤维蛋白原、C反应蛋白）与急性缺血性卒中严重程度及预后的相关性。
该研究纳入了61例缺血性卒中患者和64例对照。根据TOAST标准对卒中进行亚型分类，测量卒中的严重程度及（1年时的）预后。
病例组的平均甘油三酯、纤维蛋白原、C反应蛋白和血糖值显著更高。大动脉粥样硬化（LAA）型卒中患者的氧化型低密度脂蛋白中位数显著高于其他亚型。氧化型低密度脂蛋白值与年龄、卒中严重程度及预后无关。
炎症标志物（纤维蛋白原和C反应蛋白）可预测卒中严重程度及预后，而氧化型低密度脂蛋白水平升高则不能。我们的数据提示卒中的LAA亚型与氧化型低密度脂蛋白（载脂蛋白B100醛修饰形式）升高之间可能存在某些联系。
