Guldiken Baburhan, Guldiken Sibel, Turgut Burhan, Turgut Nilda, Demir Muzaffer, Celik Yahya, Arikan Ender, Tugrul Armagan
Department of Neurology, Social Security Hospital, Trakya University Medical Faculty, Edirne, Turkey.
Angiology. 2008 Apr-May;59(2):224-9. doi: 10.1177/0003319707304134. Epub 2008 Apr 2.
The role of circulating, oxidized low-density lipoprotein and interleukin-6 levels in acute ischemic stroke considering the primary-vessel disease was investigated. The study consisted of 28 patients with acute ischemic stroke and 23 control subjects. Patients were subdivided into large-vessel (n = 12) and small-vessel (n =16) disease stroke groups according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria. The means of oxidized low-density lipoprotein and interleukin-6 levels of patients with acute ischemic stroke were higher than controls (P < .01, P < .05). Mean oxidized low-density lipoprotein level was higher in the large-vessel disease group than in the small-vessel disease group (P < .01). The mean of inteleukin-6 levels was higher in the small-vessel disease group (P < .01). The results of the present study showed that oxidative stress promotes large-vessel disease rather than small-vessel disease stroke, and inflammation may play important an role in the development of small-vessel disease stroke.
研究了考虑主要血管疾病时循环氧化低密度脂蛋白和白细胞介素-6水平在急性缺血性卒中中的作用。该研究包括28例急性缺血性卒中患者和23例对照受试者。根据急性卒中治疗中Org 10172试验（TOAST）标准，将患者分为大血管（n = 12）和小血管（n = 16）疾病卒中组。急性缺血性卒中患者的氧化低密度脂蛋白和白细胞介素-6水平均值高于对照组（P <.01，P <.05）。大血管疾病组的平均氧化低密度脂蛋白水平高于小血管疾病组（P <.01）。小血管疾病组的白细胞介素-6水平均值更高（P <.01）。本研究结果表明，氧化应激促进大血管疾病而非小血管疾病性卒中，并且炎症可能在小血管疾病性卒中的发生中起重要作用。
