在德国一家急症医院的一株耐碳青霉烯类弗氏柠檬酸杆菌临床分离株中首次检测到VIM-1金属β-内酰胺酶。
First detection of a VIM-1 metallo-beta-lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany.
作者信息
Weile Jan, Rahmig Harald, Gfröer Sabine, Schroeppel Klaus, Knabbe Cornelius, Susa Milorad
机构信息
Department of Clinical Chemistry and Laboratory Medicine, Robert Bosch Hospital, Stuttgart, Germany.
出版信息
Scand J Infect Dis. 2007;39(3):264-6. doi: 10.1080/00365540600868388.
We report the first detection of a carbapenem-resistant Citrobacter freundii clinical strain in Germany. It was isolated from an abscess of a patient with acute necrotic pancreatitis in an acute hospital. PCR and sequencing experiments revealed that the carbapenem resistance was mediated by a VIM-1 metallo-beta-lactamase, located on a plasmid encoded class 1 integron. Carbapenem resistance in Enterobacteriaceae is so far a rare event and 1 of the major therapeutic concerns in the future.
我们报告了在德国首次检测到一株耐碳青霉烯类弗氏柠檬酸杆菌临床菌株。它是从一家急症医院一名急性坏死性胰腺炎患者的脓肿中分离出来的。聚合酶链反应（PCR）和测序实验表明，碳青霉烯类耐药性由位于1类整合子编码质粒上的VIM-1金属β-内酰胺酶介导。迄今为止，肠杆菌科细菌中的碳青霉烯类耐药性是一种罕见事件，也是未来主要的治疗关注点之一。
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