Longmuir Reid, Lee Andrew G, Rouleau Jacinthe
University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Semin Ophthalmol. 2007 Jan-Mar;22(1):49-53. doi: 10.1080/08820530601182725.
To describe a case of cotton wool spots associated with interferon beta-1a treatment.
Observational case report.
A 40-year-old man with a history of multiple sclerosis was on interferon beta-1a. He presented with cotton wool spots on fundus exam, which resolved and then recurred all while on therapy. Interferon was discontinued after the second episode and again the cotton wool spots resolved. Upon restarting the interferon, no further cotton wool spots have recurred.
To our knowledge this represents only the third case of interferon beta-1a associated cotton wool patches and the first in the English-language ophthalmic literature. Unlike interferon alpha therapy, interferon beta 1-a retinopathy is presumed to be extremely rare and more common etiologies for cotton wool spots should be excluded in these patients. Given this limited number of cases versus the relatively frequent use of interferon beta-1a in the management of multiple sclerosis, no conclusions regarding causality or screening can be made but the issue probably deserves further study.
描述一例与干扰素β-1a治疗相关的棉絮斑病例。
观察性病例报告。
一名患有多发性硬化症病史的40岁男性正在接受干扰素β-1a治疗。眼底检查发现其出现棉絮斑，在治疗期间这些棉絮斑消退后又复发。第二次发作后停用了干扰素，棉絮斑再次消退。重新开始使用干扰素后，棉絮斑未再复发。
据我们所知，这是仅有的第三例与干扰素β-1a相关的棉絮斑病例，也是英文眼科文献中的首例。与干扰素α治疗不同，干扰素β-1a所致视网膜病变被认为极为罕见，对于这些患者应排除更常见的棉絮斑病因。鉴于与在多发性硬化症治疗中相对频繁使用干扰素β-1a相比病例数量有限，无法就因果关系或筛查得出结论，但这个问题可能值得进一步研究。
