[β-干扰素视网膜病变]
[Interferon-beta retinopathy].
作者信息
Sallansonnet-Froment M, Roux X, de Greslan T, Bounolleau P, Taillia H, Ricard D, Ouologuem M, Renard J L
机构信息
Service de neurologie, hôpital d'instruction-des-Armées du Val-de-Grâce, 74, boulevard de Port-Royal, 75230 Paris cedex 05, France.
出版信息
Rev Neurol (Paris). 2009 Nov;165(11):971-4. doi: 10.1016/j.neurol.2008.11.019. Epub 2009 Jan 14.
INTRODUCTION
Interferon-alpha associated retinopathy is an ocular complication of hepatitis C treatment well established in the literature. But, there are far fewer reports on multiple sclerosis related interferon-beta retinopathy.
CASE REPORT
A 58-year-old male while receiving subcutaneous interferon-beta 1a 44microg thrice a week since 2001 for multiple sclerosis developed blurred vision. Visual acuity remained stable throughout the course of surveillance. Cotton wool spots were found on fundus exam. The retinopathy disappeared without specific therapy 2 months after discontinuing interferon injections. The diagnosis of interferon-beta 1a retinopathy was retained due to the lack of any other etiology.
CONCLUSION
An ophthalmological examination including a fundus examination to search for a retinopathy should be undertaken when new ocular symptoms develop in a multiple sclerosis patient receiving interferon. An adverse event linked to interferon can be discussed and favored if the retinopathy resolves after interferon withdrawal.
引言
干扰素-α相关性视网膜病变是丙型肝炎治疗的一种眼部并发症，在文献中已有充分记载。但是，关于多发性硬化症相关的干扰素-β视网膜病变的报道要少得多。
病例报告
一名58岁男性自2001年起每周三次皮下注射44微克干扰素-β1a治疗多发性硬化症，出现视力模糊。在整个监测过程中视力保持稳定。眼底检查发现棉絮斑。停止注射干扰素2个月后，视网膜病变未经特殊治疗即消失。由于缺乏任何其他病因，故诊断为干扰素-β1a视网膜病变。
结论
接受干扰素治疗的多发性硬化症患者出现新的眼部症状时，应进行包括眼底检查在内的眼科检查以寻找视网膜病变。如果视网膜病变在停用干扰素后消失，则可以讨论并认为存在与干扰素相关的不良事件。
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