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共济失调性构音障碍的神经基础。

The neural basis of ataxic dysarthria.

作者信息

Spencer Kristie A, Slocomb Dana L

机构信息

Department of Speech and Hearing Sciences, University of Washington, 1417 NE 42nd Street, Seattle, WA 98105, USA.

出版信息

Cerebellum. 2007;6(1):58-65. doi: 10.1080/14734220601145459.

DOI:10.1080/14734220601145459
PMID:17366266
Abstract

Lesions to the cerebellum often give rise to ataxic dysarthria which is characterized by a primary disruption to articulation and prosody. Converging evidence supports the likelihood of speech motor programming abnormalities in addition to speech execution deficits. The understanding of ataxic dysarthria has been further refined by the development of neural network models and neuroimaging studies. A critical role of feedforward processing by the cerebellum has been established and linked to speech motor control and to aspects of ataxic dysarthria. Moreover, this research has helped to define models of the cerebellar contributions to speech processing and production, and to posit possible regions of speech localization within the cerebellum. Bilateral, superior areas of the cerebellum appear to mediate speech motor control while a putative role of the right cerebellar hemispheres in the planning and processing of speech has been suggested.

摘要

小脑病变常导致共济失调性构音障碍,其特征是发音和韵律出现原发性障碍。越来越多的证据表明,除了言语执行缺陷外,还可能存在言语运动编程异常。神经网络模型和神经影像学研究的发展进一步完善了对共济失调性构音障碍的认识。小脑前馈处理的关键作用已得到确立,并与言语运动控制及共济失调性构音障碍的各个方面相关联。此外,这项研究有助于明确小脑对言语处理和产生的贡献模型,并推测小脑内可能的言语定位区域。小脑的双侧上部区域似乎介导言语运动控制,同时有人提出右小脑半球在言语规划和处理中具有假定作用。

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