Parazzini F, Negri E, La Vecchia C, Restelli C, Franceschi S
Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy.
Am J Epidemiol. 1992 Jan 1;135(1):35-40. doi: 10.1093/oxfordjournals.aje.a116199.
The relation between family history of ovarian, breast, and endometrial cancer and risk of epithelial ovarian carcinoma was analyzed within the framework of a case-control study conducted from 1983 to 1989. The study included 755 cases of ovarian cancer and 2,023 controls in hospital for a spectrum of acute nongynecologic, hormonal, or neoplastic conditions in the Greater Milan area, Italy. Eighteen cases (2%) and 24 controls (1%) reported a history of ovarian cancer in a first-degree relative: The corresponding multivariate adjusted odds ratio (OR) was 1.9 (95% confidence interval (CI) 1.1-3.6). The risk of ovarian cancer was elevated in women reporting a family history of breast cancer (OR = 1.6, 95% CI 1.1-2.3), but no significant association emerged with a family history of endometrial cancer (OR = 1.3, 95% CI 0.8-1.7). When the data were stratified by family history of breast cancer, a family history of ovarian cancer was over 10 times more frequent in both cases and controls who reported a family history of breast cancer than in cases and controls reporting no family history of breast cancer. The estimated odds ratio for ovarian cancer associated with a family history of the disease was 2.3 (95% CI 1.1-4.5) in women not reporting a family history of breast cancer, but no association emerged in the subgroup of women reporting a family history of breast cancer. These results confirm that a family history of ovarian cancer increases the risk of the disease, but the percentage of ovarian cancer cases explained by a family history of the disease is small: Less than 1% of observed cases in this study could be attributed to this "family risk factor."
在1983年至1989年开展的一项病例对照研究框架内，分析了卵巢癌、乳腺癌和子宫内膜癌家族史与上皮性卵巢癌风险之间的关系。该研究纳入了意大利大米兰地区因一系列急性非妇科、激素或肿瘤性疾病住院的755例卵巢癌病例和2023例对照。18例病例（2%）和24例对照（1%）报告有一级亲属患卵巢癌的病史：相应的多变量调整优势比（OR）为1.9（95%置信区间（CI）1.1 - 3.6）。报告有乳腺癌家族史的女性患卵巢癌的风险升高（OR = 1.6，95% CI 1.1 - 2.3），但与子宫内膜癌家族史未出现显著关联（OR = 1.3，95% CI 0.8 - 1.7）。当数据按乳腺癌家族史分层时，报告有乳腺癌家族史的病例和对照中，有卵巢癌家族史的频率比未报告有乳腺癌家族史的病例和对照高出10倍以上。在未报告有乳腺癌家族史的女性中，与卵巢癌家族史相关的估计优势比为2.3（95% CI 1.1 - 4.5），但在报告有乳腺癌家族史的女性亚组中未出现关联。这些结果证实，卵巢癌家族史会增加患该疾病的风险，但由该疾病家族史解释的卵巢癌病例百分比很小：本研究中观察到的病例中不到1%可归因于这种“家族风险因素”。
