EGA Institute for Women's Health, Gynaecological Cancer Research Laboratories, University College London, London, UK.
Curr Opin Genet Dev. 2010 Jun;20(3):231-8. doi: 10.1016/j.gde.2010.03.001. Epub 2010 Apr 24.
Endometrial and epithelial ovarian cancers are the fourth and fifth most common cancers in women in developed countries, after breast, lung, and colorectal cancer. In the United States alone, in 2008 there were about 40,000 new diagnoses of endometrial cancer and 7500 disease-related deaths. For ovarian cancer, there were about 22,000 new diagnoses and 15,000 deaths over the same period. The purpose of this article is to review the recent developments in the inherited genetics of ovarian and endometrial cancer, with particular attention to recent progress in identifying common low-penetrance susceptibility genes and their clinical implications.
在发达国家，子宫内膜癌和上皮性卵巢癌是女性中第四和第五大常见癌症，排在乳腺癌、肺癌和结直肠癌之后。仅在美国，2008 年就有约 4 万例子宫内膜癌新发病例和 7500 例与疾病相关的死亡。同期卵巢癌的新发病例约为 2.2 万例，死亡约 1.5 万例。本文旨在综述卵巢癌和子宫内膜癌遗传易感性的最新研究进展，特别关注识别常见低外显率易感基因的最新进展及其临床意义。
