Bernardi Maria José, Reis Alessandra, Loguercio Alessandro Dourado, Kehrig Ruth, Leite Mariana Ferreira, Nicolau José
University of Oeste de Santa Catarina, Campus Joaçaba, SC, Brazil.
Oral Health Prev Dent. 2007;5(1):73-8.
This study measured the flow rate, pH and buffering capacity of saliva from well- and poorly metabolically controlled Type 2 diabetic patients in three cities of the southern part of Brazil, compared with healthy individuals from the same cities.
Whole saliva was collected by mechanical stimulation and buffering capacity and glucose level were measured. Blood was collected after 12 hours fasting and glucose and glycosylated haemoglobin concentrations were determined. The data were analysed by one-way ANOVA and Student-Newman-Keuls (alpha= 0.05).
The flow rate was lower in the Type 2 diabetic patients, regardless of whether they were well or poorly metabolically controlled, compared with healthy individuals (p < 0.05). Salivary glucose concentration was higher in both diabetic patient groups, i.e. well and poorly metabolically controlled, than in the control (p < 0.05).
The metabolic control of hyperglycaemia was not sufficient to improve the salivary flow rate or the salivary glucose concentration.
本研究测量了巴西南部三个城市代谢控制良好和控制不佳的2型糖尿病患者唾液的流速、pH值和缓冲能力,并与来自同一城市的健康个体进行比较。
通过机械刺激收集全唾液,并测量缓冲能力和葡萄糖水平。空腹12小时后采集血液,测定葡萄糖和糖化血红蛋白浓度。数据采用单因素方差分析和Student-Newman-Keuls检验(α=0.05)进行分析。
与健康个体相比,2型糖尿病患者的流速较低,无论其代谢控制良好或不佳(p<0.05)。代谢控制良好和控制不佳的两组糖尿病患者的唾液葡萄糖浓度均高于对照组(p<0.05)。
高血糖的代谢控制不足以改善唾液流速或唾液葡萄糖浓度。