Shetty Jyothi, Hegde Mithra N, Kumari N Suchetha, D'Souza Neevan, Shetty Shilpa S
Department of Conservative Dentistry and Endodontics, A B Shetty Memorial Institute of Dental Sciences, Nitte (Deemed to be University), Mangalore, Karnataka, India.
Department of Biochemistry, K S Hegde Medical Academy, Nitte (Deemed to be University), Mangalore, Karnataka, India.
J Conserv Dent Endod. 2025 May;28(5):406-411. doi: 10.4103/JCDE.JCDE_791_24. Epub 2025 May 6.
The objectives of this study were to assess the salivary flow rate, pH, buffering capacity, and glycoproteins levels in root caries-active and root caries (RC)-free subjects.
A cross-sectional study was conducted in the Outpatient Department of A B Shetty Memorial Institute of Dental Sciences with a sample size of 94 subjects. After screening of the subjects, the salivary samples were collected from 47 RC-active and 47 RC-free subjects for analysis. The following parameters were assessed - salivary flow rate, pH, buffer capacity, levels of salivary amylase, mucin, albumin, globulin, and total salivary protein.
Age was significantly higher in the RC group compared to the non-RC group ( < 0.001). There was no significant difference in pH between the groups ( = 0.050). Median buffer capacity and flow rate were higher in the non-RC group compared to the RC group. There was a significant difference in buffer capacity ( < 0.001) and flow rate ( = 0.001) between the RC and non-RC groups. There was no significant difference in total protein level ( = 0.285) in the non-RC and RC groups.
The study demonstrated reduced salivary flow and buffer capacity, along with lower albumin levels and higher mucin-1 concentrations in individuals with RC. The salivary analysis provides a noninvasive and effective approach to assess RC risk. Incorporating salivary diagnostics into routine dental check-ups, particularly for older patients, can help in tailoring preventive care and treatment plans.
本研究的目的是评估根龋活跃和无根龋（RC）受试者的唾液流速、pH值、缓冲能力和糖蛋白水平。
在AB谢蒂纪念牙科学院门诊部进行了一项横断面研究，样本量为94名受试者。在对受试者进行筛查后，从47名根龋活跃受试者和47名无根龋受试者中收集唾液样本进行分析。评估了以下参数——唾液流速、pH值、缓冲能力、唾液淀粉酶、粘蛋白、白蛋白、球蛋白和唾液总蛋白水平。
与非根龋组相比，根龋组的年龄显著更高（<0.001）。两组之间的pH值无显著差异（=0.050）。与根龋组相比，非根龋组的中位缓冲能力和流速更高。根龋组和非根龋组之间的缓冲能力（<0.001）和流速（=0.001）存在显著差异。非根龋组和根龋组的总蛋白水平无显著差异（=0.285）。
该研究表明，根龋患者的唾液流速和缓冲能力降低，同时白蛋白水平较低，粘蛋白-1浓度较高。唾液分析提供了一种评估根龋风险的非侵入性有效方法。将唾液诊断纳入常规牙科检查，特别是对老年患者，有助于制定个性化的预防护理和治疗计划。
