无糖牙膏和普通牙膏对2型糖尿病患者唾液葡萄糖及pH值的影响——一项随机交叉试验
Effect of Sugar-Free and Regular Toothpaste on Salivary Glucose and pH among Type 2 Diabetes- A Randomized Crossover Trial.
作者信息
Kapadia Junaid, Dodamani Arun, Baviskar Priya, Karibasappa G N, Pathak Parag, Bezalwar Abhishek
机构信息
Assistant Professor, Department of Public Health Dentisry, Bhabha College of Dental Sciences, Bhopal, Madhya Pradesh, India.
Professor and Head, Department of Public Health Dentisry, ACPM Dental College and Hospital, Dhule, Maharashtra, India.
出版信息
J Clin Diagn Res. 2017 Jul;11(7):ZC71-ZC75. doi: 10.7860/JCDR/2017/25580.10250. Epub 2017 Jul 1.
INTRODUCTION
Diabetes is one of the most prevalent diseases of mankind having general as well as oral health manifestations. Also, there is an increase of salivary glucose level in diabetic, inducing saccharolytic bacteria in saliva which can have adverse effects on oral tissue.
AIM
To assess and compare the effect of sugar-free toothpaste on salivary glucose and pH among Type 2 diabetic and non-diabetic individuals.
MATERIALS AND METHODS
A randomized controlled-crossover study was carried out on 30 Type 2 diabetic (Group A) and 45 non-diabetic (Group B) subjects. In first half of study, subjects in Group A and Group B were intervened with sugar-free and regular toothpaste respectively. Salivary glucose and pH was assessed before and after brushing at interval of one week for a period of four weeks. In second half, toothpastes were switched over between the groups, after sufficient washout period. Salivary glucose and pH were assessed again in the same manner for both the groups. The data was subjected to paired t-test and unpaired t-test for intragroup and intergroup comparison respectively.
RESULTS
Salivary glucose level was significantly reduced and salivary pH was increased significantly (p<0.001) in both groups with sugar free toothpaste when compared to regular toothpaste.
CONCLUSION
Sugar free toothpaste showed beneficial effect on salivary glucose level and salivary pH level on diabetes and non-diabetes population.
引言
糖尿病是人类最常见的疾病之一，会影响全身健康以及口腔健康。此外，糖尿病患者唾液中的葡萄糖水平会升高，促使唾液中产生分解糖类的细菌，这可能会对口腔组织产生不利影响。
目的
评估并比较无糖牙膏对2型糖尿病患者和非糖尿病患者唾液葡萄糖及pH值的影响。
材料与方法
对30名2型糖尿病患者（A组）和45名非糖尿病患者（B组）进行了一项随机对照交叉研究。在研究的前半段，A组和B组的受试者分别使用无糖牙膏和普通牙膏进行干预。在四周的时间里，每隔一周在刷牙前后评估唾液葡萄糖和pH值。在后半段，经过足够的洗脱期后，两组交换牙膏。两组再次以相同方式评估唾液葡萄糖和pH值。数据分别进行配对t检验和非配对t检验，以进行组内和组间比较。
结果
与普通牙膏相比，两组使用无糖牙膏时唾液葡萄糖水平显著降低，唾液pH值显著升高（p<0.001）。
结论
无糖牙膏对糖尿病和非糖尿病人群的唾液葡萄糖水平和唾液pH值有有益影响。
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