Huss Anke, Egger Matthias, Hug Kerstin, Huwiler-Müntener Karin, Röösli Martin
Department of Social and Preventive Medicine, University of Berne, Berne, Switzerland.
Environ Health Perspect. 2007 Jan;115(1):1-4. doi: 10.1289/ehp.9149.
OBJECTIVES: There is concern regarding the possible health effects of cellular telephone use. We examined whether the source of funding of studies of the effects of low-level radiofrequency radiation is associated with the results of studies. We conducted a systematic review of studies of controlled exposure to radiofrequency radiation with health-related outcomes (electroencephalogram, cognitive or cardiovascular function, hormone levels, symptoms, and subjective well-being). DATA SOURCES: We searched EMBASE, Medline, and a specialist database in February 2005 and scrutinized reference lists from relevant publications. DATA EXTRACTION: Data on the source of funding, study design, methodologic quality, and other study characteristics were extracted. The primary outcome was the reporting of at least one statistically significant association between the exposure and a health-related outcome. Data were analyzed using logistic regression models. DATA SYNTHESIS: Of 59 studies, 12 (20%) were funded exclusively by the telecommunications industry, 11 (19%) were funded by public agencies or charities, 14 (24%) had mixed funding (including industry), and in 22 (37%) the source of funding was not reported. Studies funded exclusively by industry reported the largest number of outcomes, but were least likely to report a statistically significant result: The odds ratio was 0.11 (95% confidence interval, 0.02-0.78), compared with studies funded by public agencies or charities. This finding was not materially altered in analyses adjusted for the number of outcomes reported, study quality, and other factors. CONCLUSIONS: The interpretation of results from studies of health effects of radiofrequency radiation should take sponsorship into account.
目的:人们对使用移动电话可能产生的健康影响表示担忧。我们研究了低水平射频辐射影响研究的资金来源是否与研究结果相关。我们对暴露于射频辐射与健康相关结局(脑电图、认知或心血管功能、激素水平、症状和主观幸福感)的对照研究进行了系统评价。 数据来源:我们于2005年2月检索了EMBASE、Medline和一个专业数据库,并仔细查阅了相关出版物的参考文献列表。 数据提取:提取了关于资金来源、研究设计、方法学质量和其他研究特征的数据。主要结局是报告暴露与健康相关结局之间至少有一项具有统计学意义的关联。使用逻辑回归模型分析数据。 数据综合:在59项研究中,12项(20%)完全由电信行业资助,11项(19%)由公共机构或慈善机构资助,14项(24%)有混合资金(包括行业资金),22项(37%)未报告资金来源。完全由行业资助的研究报告的结局数量最多,但报告具有统计学意义结果的可能性最小:与由公共机构或慈善机构资助的研究相比,优势比为0.11(95%置信区间,0.02 - 0.78)。在根据报告的结局数量、研究质量和其他因素进行调整的分析中,这一发现没有实质性改变。 结论:对射频辐射健康影响研究结果的解释应考虑资助情况。