唇腭裂的胚胎学与流行病学

Embryology and epidemiology of cleft lip and palate.

作者信息

Bernheim N, Georges M, Malevez C, De Mey A, Mansbach A

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, The Cleft Lip and Palate Team, Hôpital Universitaire des Enfants Reine Fabiola, Brussels, Belgium.

出版信息

B-ENT. 2006;2 Suppl 4:11-9.

DOI:

PMID:17366840

Abstract

Craniofacial anomalies, in particular cleft lip and palate, are major human birth defects with a worldwide frequency of 1 in 700 and substantial clinical impact. This article reviews the embryology of the face, lip, and palate to enhance the understanding of the pathogenesis of these lesions, with particular attention to the period of susceptibility during gestation, complexity, and the factors that may influence their development. It includes an overview of the prevalence and environmental and genetic causes of cleft lip-with or without cleft palate- and cleft palate.

摘要

颅面畸形，尤其是唇腭裂，是主要的人类出生缺陷，在全球范围内的发生率为1/700，具有重大的临床影响。本文回顾了面部、唇部和腭部的胚胎学，以增进对这些病变发病机制的理解，特别关注妊娠期的易感性时期、复杂性以及可能影响其发育的因素。它包括唇裂（伴或不伴腭裂）和腭裂的患病率、环境和遗传原因的概述。