Habib Z
Surg Gynecol Obstet. 1978 Jan;146(1):105-10.
The modern care of newborn infants with oral clefts renders their survival possible. Since they will eventually reproduce, a slight increase in the incidence may be expected and genetic counseling will be requested on occasion. The cleft lip with or without cleft palate has a different genetic inclination from isolated cleft palate and the risk of recurrence is different. Drugs, such as antiepileptics, salicylates, benzodiazepines and cortisone, have a role in causing oral clefts. When an oral cleft is a part of a syndrome, the genetics of the particular syndrome must be outlined and genetic counseling is given accordingly. Oral clefts alone are usually multifactorial.
现代对唇腭裂新生儿的护理使其存活成为可能。由于他们最终会生育，预计发病率会略有上升，并且有时会需要遗传咨询。唇裂伴或不伴腭裂与单纯腭裂有不同的遗传倾向，复发风险也不同。药物，如抗癫痫药、水杨酸盐、苯二氮䓬类药物和皮质醇，在导致唇腭裂方面起一定作用。当唇腭裂是某一综合征的一部分时，必须概述该特定综合征的遗传学情况，并据此进行遗传咨询。单纯唇腭裂通常是多因素的。
