Wan Qi-Hui, Wang Jia-Li, He Li-Fang, Liu Hui, Zhang Xi
Department of Parasitology, Zunyi Medical College, Zunyi 563003, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2006 Dec;24(6):475-6.
Kunming mice were infected by feeding 150+/-5 larvae of Trichinella spiralis, established was also a normal control group. Blood was collected from the ophthalmic venous plexus respectively on 7 d, 21 d, 35 d and 49 d after infection and IL-12 in the serum was detected by ELISA. The level of IL-12 in serum decreased in groups of 7 d, 21 d, and 35 d, with a significant difference to the control (P<0.01). However, there was no significant difference between 49d group and control (P>0.05), suggesting that the serum IL-12 of the Trichinella spiralis-infected mice significantly decreased at the earlier stage but approached to normal at a later stage.
通过喂饲150±5条旋毛虫幼虫感染昆明小鼠，同时设立正常对照组。分别于感染后7天、21天、35天和49天从眼静脉丛采血，用ELISA法检测血清中IL-12水平。感染后7天、21天和35天组血清IL-12水平下降，与对照组相比差异有统计学意义（P<0.01）。然而，49天组与对照组之间差异无统计学意义（P>0.05），提示旋毛虫感染小鼠血清IL-12在早期显著下降，后期接近正常。
