基于机制的苯甲酰甲酸脱羧酶失活，一种依赖硫胺素二磷酸的酶。 - Suppr

Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme.

作者信息

Bera Asim K, Polovnikova Lena S, Roestamadji Juliatek, Widlanski Theodore S, Kenyon George L, McLeish Michael J, Hasson Miriam S

机构信息

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

出版信息

J Am Chem Soc. 2007 Apr 11;129(14):4120-1. doi: 10.1021/ja068636z. Epub 2007 Mar 17.

DOI:10.1021/ja068636z

PMID:17367138

Abstract

摘要

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Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme.基于机制的苯甲酰甲酸脱羧酶失活，一种依赖硫胺素二磷酸的酶。

J Am Chem Soc. 2007 Apr 11;129(14):4120-1. doi: 10.1021/ja068636z. Epub 2007 Mar 17.

Factors mediating activity, selectivity, and substrate specificity for the thiamin diphosphate-dependent enzymes benzaldehyde lyase and benzoylformate decarboxylase.介导硫胺素二磷酸依赖性酶苯甲醛裂解酶和苯甲酰甲酸脱羧酶的活性、选择性和底物特异性的因素。

Chembiochem. 2006 Dec;7(12):1928-34. doi: 10.1002/cbic.200600277.

Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.硫胺素二磷酸依赖性酶苯甲酰甲酸脱羧酶催化作用的结构与动力学分析

Biochemistry. 2003 Feb 25;42(7):1820-30. doi: 10.1021/bi026490k.

Intermediates and transition states in thiamin diphosphate-dependent decarboxylases. A kinetic and NMR study on wild-type indolepyruvate decarboxylase and variants using indolepyruvate, benzoylformate, and pyruvate as substrates.硫胺素二磷酸依赖性脱羧酶中的中间体和过渡态。使用吲哚丙酮酸、苯甲酰甲酸和丙酮酸作为底物对野生型吲哚丙酮酸脱羧酶及其变体进行的动力学和核磁共振研究。

Biochemistry. 2005 Apr 26;44(16):6164-79. doi: 10.1021/bi0473354.

The crystal structure of benzoylformate decarboxylase at 1.6 A resolution: diversity of catalytic residues in thiamin diphosphate-dependent enzymes.苯甲酸甲酸脱羧酶1.6埃分辨率的晶体结构：硫胺素二磷酸依赖性酶中催化残基的多样性

Biochemistry. 1998 Jul 14;37(28):9918-30. doi: 10.1021/bi973047e.

Propioin synthesis using thiamine diphosphate-dependent enzymes.使用硫胺素二磷酸依赖性酶的丙氨酸合成。（注：原文中的Propioin可能有误，推测应该是Propionine，即丙氨酸，翻译按此推测进行。若原文无误，Propioin这个词在医学专业中无常见对应准确释义，可能是生僻或错误表述。）

Biotechnol Prog. 2009 Jan-Feb;25(1):132-8. doi: 10.1002/btpr.55.

Alteration of the substrate specificity of benzoylformate decarboxylase from Pseudomonas putida by directed evolution.通过定向进化改变恶臭假单胞菌苯甲酸脱羧酶的底物特异性。

Chembiochem. 2003 Aug 4;4(8):721-6. doi: 10.1002/cbic.200200475.

Multiple modes of active center communication in thiamin diphosphate-dependent enzymes.硫胺素二磷酸依赖性酶中活性中心的多种通讯模式。

Acc Chem Res. 2005 Sep;38(9):755-63. doi: 10.1021/ar040244e.

Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.底物结合前酶结合硫胺素二磷酸的化学性质阐释：确定互变异构体和电离状态之间的内部平衡。

Biochemistry. 2007 Sep 18;46(37):10739-44. doi: 10.1021/bi700838q. Epub 2007 Aug 23.

Domain relationships in thiamine diphosphate-dependent enzymes.硫胺素二磷酸依赖性酶中的结构域关系。

Acc Chem Res. 2006 Aug;39(8):550-7. doi: 10.1021/ar068022z.

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Specific inhibition by synthetic analogs of pyruvate reveals that the pyruvate dehydrogenase reaction is essential for metabolism and viability of glioblastoma cells.丙酮酸合成类似物的特异性抑制作用表明，丙酮酸脱氢酶反应对于胶质母细胞瘤细胞的代谢和生存能力至关重要。

Oncotarget. 2015 Nov 24;6(37):40036-52. doi: 10.18632/oncotarget.5486.

Covalently bound substrate at the regulatory site of yeast pyruvate decarboxylases triggers allosteric enzyme activation.共价结合在酵母丙酮酸脱羧酶调节位点的底物会触发变构酶激活。

J Biol Chem. 2009 May 1;284(18):12136-44. doi: 10.1074/jbc.M806228200. Epub 2009 Feb 26.

Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.通过取代和伪底物类似物苯甲酰膦酸甲酯探究苯甲醛裂解酶的活性中心。

Biochemistry. 2008 Jul 22;47(29):7734-43. doi: 10.1021/bi8004413. Epub 2008 Jun 21.

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Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme.

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