Duggleby Ronald G
School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland 4072, Australia.
Acc Chem Res. 2006 Aug;39(8):550-7. doi: 10.1021/ar068022z.
Three-dimensional structures have been determined for 13 different enzymes that use thiamine diphosphate (ThDP) as a cofactor. These enzymes fall into five families, where members within a family have similar structures. In different families, there are similarities between some domains that clearly point to a common ancestor for all of these enzymes. Where the enzyme structures differ, evolutionary relationships between families can be discerned. Here, I present an analysis of these families and propose an evolutionary pathway to explain the diversity of structures that are now known.
已经确定了13种不同的以硫胺素二磷酸（ThDP）为辅因子的酶的三维结构。这些酶分为五个家族，同一家族的成员具有相似的结构。在不同家族中，一些结构域之间存在相似性，这清楚地表明所有这些酶都有一个共同的祖先。在酶结构不同的地方，可以辨别出家族之间的进化关系。在这里，我对这些家族进行了分析，并提出了一条进化途径来解释目前已知的结构多样性。
