Torkhovskaya T I, Ipatova O M, Zakharova T S, Kochetova M M, Khalilov E M
Institute of Physico-Chemical Medicine, Moscow, Russia.
Biochemistry (Mosc). 2007 Feb;72(2):125-31. doi: 10.1134/s0006297907020010.
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors. G-Protein coupled signal transduction to the cell nucleus involving a chain of intracellular protein kinases induces the main effects in cells--growth, proliferation, survival, or apoptosis. This review summarizes recent data on various groups of lysophospholipid receptors and their cell signal transduction pathways.
越来越多的证据表明，不同的磷脂参与了各种细胞过程和细胞间相互作用的调节。溶血磷脂（溶血磷脂酸、溶血磷脂酰胆碱）和一些神经酰胺在这些调节中发挥着特殊作用。它们的作用是由特定的G蛋白偶联受体介导的。G蛋白偶联信号转导至细胞核，涉及一系列细胞内蛋白激酶，从而在细胞中诱导主要效应——生长、增殖、存活或凋亡。本综述总结了关于溶血磷脂受体各基团及其细胞信号转导途径的最新数据。
