Beeres Saskia L M A, Bengel Frank M, Bartunek Jozef, Atsma Douwe E, Hill Jonathan M, Vanderheyden Marc, Penicka Martin, Schalij Martin J, Wijns William, Bax Jeroen J
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
J Am Coll Cardiol. 2007 Mar 20;49(11):1137-48. doi: 10.1016/j.jacc.2006.10.072. Epub 2007 Mar 6.
Stem cell therapy has emerged as a potential therapeutic option for cell death-related heart diseases. Preclinical and a number of early phase human studies suggested that cell therapy may augment perfusion and increase myocardial contractility. The rapid translation into clinical trials has left many issues unresolved, and emphasizes the need for specific techniques to visualize the mechanisms involved. Furthermore, the clinical efficacy of cell therapy remains to be proven. Imaging allows for in vivo tracking of cells and can provide a better understanding in the evaluation of the functional effects of cell-based therapies. In this review, a summary of the most promising imaging techniques for cell tracking is provided. Among these are direct labeling of cells with super-paramagnetic agents, radionuclides, and the use of reporter genes for imaging of transplanted cells. In addition, a comprehensive summary is provided of the currently available studies investigating a cell therapy-related effect on left ventricular function, myocardial perfusion, scar tissue, and myocardial viability.
干细胞疗法已成为与细胞死亡相关的心脏病的一种潜在治疗选择。临床前研究和一些早期人体研究表明，细胞疗法可能会增加灌注并增强心肌收缩力。迅速进入临床试验使得许多问题尚未解决，并强调需要特定技术来可视化其中涉及的机制。此外，细胞疗法的临床疗效仍有待证实。成像技术能够在体内追踪细胞，并有助于更好地理解基于细胞的疗法的功能效果评估。在本综述中，总结了最有前景的细胞追踪成像技术。其中包括用超顺磁性剂、放射性核素直接标记细胞，以及使用报告基因对移植细胞进行成像。此外，还全面总结了目前有关细胞疗法对左心室功能、心肌灌注、瘢痕组织和心肌活力相关影响的现有研究。
