Tomiya Masayuki, Fukushima Takeshi, Watanabe Hiroyuki, Fukami Goro, Fujisaki Mihisa, Iyo Masaomi, Hashimoto Kenji, Mitsuhashi Shogo, Toyo'oka Toshimasa
Division of Bio-Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
Clin Chim Acta. 2007 May 1;380(1-2):186-90. doi: 10.1016/j.cca.2007.02.011. Epub 2007 Feb 15.
Since several studies have investigated gender-related differences in the onset of disease, response to drug therapy, etc. in schizophrenic patients, we examined the alterations in serum amino acids concentrations in male and female patients separately.
Serum amino acid concentrations in the normal (n=35; male 21 and female 14) and schizophrenic patients (n=32; male 19 and female 13) were determined by HPLC using a pre-column fluorescence derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole.
Serum glutamate and serine concentrations were significantly increased in the male schizophrenic patients (p=0.0161 and 0.0257, respectively), while the serum Pro concentration was significantly increased in female schizophrenic patients (p=0.0398). Serum Glu, Ser, and Pro concentrations in the patients did not significantly correlate with the age, age of onset of disease, duration of illness, and chlorpromazine equivalents. Among the amino acids, serum Orn concentrations in male and female schizophrenic patients positively correlated with the duration of illness (p<0.01, r=0.685 and 0.688, respectively).
The present data suggest the existence of gender-related differences in the alterations in serum amino acid concentrations in schizophrenic patients; further, serum Orn concentration in both sexes might be influenced by medications.
由于多项研究调查了精神分裂症患者在疾病发作、对药物治疗的反应等方面的性别差异，我们分别研究了男性和女性患者血清氨基酸浓度的变化。
采用4-氟-7-硝基-2,1,3-苯并恶二唑柱前荧光衍生化高效液相色谱法（HPLC）测定正常受试者（n=35；男性21例，女性14例）和精神分裂症患者（n=32；男性19例，女性13例）的血清氨基酸浓度。
男性精神分裂症患者血清谷氨酸和丝氨酸浓度显著升高（分别为p=0.0161和0.0257），而女性精神分裂症患者血清脯氨酸浓度显著升高（p=0.0398）。患者血清谷氨酸、丝氨酸和脯氨酸浓度与年龄、发病年龄、病程及氯丙嗪等效剂量均无显著相关性。在氨基酸中，男性和女性精神分裂症患者血清鸟氨酸浓度与病程呈正相关（p<0.01，r分别为0.685和0.688）。
目前的数据表明精神分裂症患者血清氨基酸浓度变化存在性别差异；此外，两性血清鸟氨酸浓度可能受药物影响。
