Morshed N M, Sobhan M A, Nahar J S, Keramat Ali S M, Shams M
Deptt. of Psychiatry, Bangabandhu Sheik Mujib Medical University, Dhaka.
Bangladesh Med Res Counc Bull. 2005 Apr;31(1):15-20.
The study presents for the first time the blood level of glutamate and aspartate in schizophrenic patients and in normal subjects in Bangladeshi population. The serum level of glutamate and aspartate were measured in thirty newly diagnosed schizophrenic patients and the same number of subjects matching age was taken from non-schizophrenic control. The age group of the patient was between 15 and 45 years and the male female ratio was 2.7:1. Serum concentration of glutamate (598.83 +/- 574.48 nmol/ml) was significantly higher (p < 0.001) in schizophrenic group compared to control (196.16 +/- 171.31 nmol/ ml). The serum asparate concentration was also significantly higher in schizophrenic cases (282.91 +/- 299.94 nmol/ml) as compared to control (33.89 +/- 42.68 nmol/ml, p < 0.001). The correlation coefficient between serum glutamate and asparate was significant (p < 0.001). The increased serum glutamate and asparate levels may be the causative or contributing factor in the pathogenesis and progression of schizophrenia.
该研究首次呈现了孟加拉人群中精神分裂症患者和正常受试者的谷氨酸和天冬氨酸血液水平。对30名新诊断的精神分裂症患者测定了血清谷氨酸和天冬氨酸水平，并从非精神分裂症对照组选取了相同数量、年龄匹配的受试者。患者年龄在15至45岁之间，男女比例为2.7:1。与对照组（196.16±171.31纳摩尔/毫升）相比，精神分裂症组的血清谷氨酸浓度（598.83±574.48纳摩尔/毫升）显著更高（p<0.001）。与对照组（33.89±42.68纳摩尔/毫升，p<0.001）相比，精神分裂症患者的血清天冬氨酸浓度也显著更高（282.91±299.94纳摩尔/毫升）。血清谷氨酸和天冬氨酸之间的相关系数具有显著性（p<0.001）。血清谷氨酸和天冬氨酸水平升高可能是精神分裂症发病机制和病情进展的致病因素或促成因素。
