Rajkumar S Vincent, Lacy Martha Q, Kyle Robert A
Division of Hematology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, United States.
Blood Rev. 2007 Sep;21(5):255-65. doi: 10.1016/j.blre.2007.01.002. Epub 2007 Mar 26.
Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic disorders characterized by monoclonal plasma cell proliferation in the bone marrow in the absence of end-organ damage. Updated diagnostic criteria for these disorders, risk-stratification models to determine prognosis, and the current management of these two entities are discussed in this review.
意义未明的单克隆丙种球蛋白病（MGUS）和冒烟型多发性骨髓瘤（SMM）是无症状性疾病，其特征为骨髓中存在单克隆浆细胞增殖且无终末器官损害。本综述讨论了这些疾病的更新诊断标准、用于确定预后的风险分层模型以及这两种疾病的当前管理方法。
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